摘要
目的探讨乳腺癌腋淋巴结微小转移与Survivin基因表达的关系。方法采用免疫组织化学SP法对34例淋巴结常规HE染色无癌转移的乳腺癌腋淋巴结572枚进行上皮细胞角蛋白19(CK-19)表达和原发癌组织进行Survivin基因表达的检测。结果淋巴结CK-19病例阳性率为26.47%(9/34),淋巴结数阳性率为4.37%(25/572)。Survivin阳性率为32.35%(11/34)。CK-19阳性病例组中Survivin阳性率为55.56%(5/9),CK-19阴性病例组中Survivin阳性率为24%(6/25),CK-19阳性组与CK-19阴性组的Survivin阳性率无显著差异(P>0.05)。结论乳腺癌腋淋巴结微小转移的发生与癌组织凋亡抑制蛋白的表达无明显相关性。
[Objective] To investigate mierometastasis in axillary lymph nodes and its relationship with Survivin gent expression of the tumor tissue in breast cancer. [Methods] 572 lymph nodes and carcinoma tissues from 34 lymph node-negative cases comtirmed by routine pathology were examined by immunohistochemical staining using CK-19 and Survivin respectively. [Results] Micrometastasis were observed in 9 cases of the 34 patients（26.47%）. The positive rate of CK-19 of axiUary node was 4.37%（25/572）. The positive rate of Survivin was 32.35%（11/34） in breast cancer tissues. The positive rate of CK-19 was no significantly relation with the expression of Survivin gene （P 〈0.05）. [Conclusion] The expression of CK-19 of axiUiaris lymph node was irrelevant to the expression of antiapoptosis gene Survivin in breast cancer fissueo
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2005年第17期2612-2614,共3页
China Journal of Modern Medicine
