摘要
为了探讨杏仁皮质内侧核群一氧化氮合酶(NOS)与运动疲劳应激的关系,观察了运动疲劳应激对大鼠杏仁皮质内侧核群NOS阳性神经元中神经元型一氧化氮合酶(nNOS)表达的影响。结果发现:疲劳组大鼠杏仁皮质前核(Aco)、杏仁内侧核(Me)和杏仁中央核(Ce)中nNOS阳性神经元数量和面积均小于对照组(P<0.05,P<0.01),其中疲劳组杏仁中央核(Ce)中nNOS阳性神经元的灰度值也明显小于对照组(P<0.01)。表明:疲劳应激可使大鼠杏仁皮质内侧核群神经元中的nNOS下调,杏仁皮质内侧核群nNOS神经元参与了中枢运动性疲劳的形成,其机理可能与杏仁皮质内侧核群神经元对应激反应的心理、行为、内分泌调节有关。
In order to explore the relationship between stress of exercise-induced fatigue and nitric oxide synthase （NOS） in medial cortical amygdaloid nuclei, it was observed that the effects of stress of exercise-induced fatigue on expression of nNOS in the nitric oxide synthase-positive neurons in rat medial cortical amygdaloid nuclei. The results show that a significant decrease of nNOS positive neurons in anterior cortical amygdaloid nucleus （Aco）, medial amygdaloid nucleus （Me）, central amygdaloid nucleus（Ce） in the number and area in fatigue group （P 〈 0.05 ,P 〈 0.01）, and a significant decrease of nNOS positive neurons in Ce in gray degree in fatigue group （P 〈 0.01 ）. It is concluded that stress of exercise-induced fatigue can induce downregulated expression of nNOS in medial cortical amygdaloid nuclei which were involved in forming of exercise-induced central fatigue, due to the psychological, behavioral, and endocrine regulation of amygdaloid nuclei on stress.
出处
《北京体育大学学报》
CSSCI
北大核心
2005年第8期1086-1088,共3页
Journal of Beijing Sport University
基金
中北大学科学基金(2004)资助项目
