摘要
对４例多发性硬化的临床和病理进行了研究。男、女各２例；年龄分别为２０岁、２６岁、２８岁及６２岁。病程分别为３２天、４５天、８年及２０年。临床表现多发病灶，主要症状和体征是视力障碍、肢体瘫痪及截瘫等，缓解复发１～４次不等。研究发现其病理改变为中枢神经系统白质多发性脱髓鞘病灶，视神经、视交叉及脊髓损害严重，脊髓又以后索及侧索损害为多见，有对称倾向。在较新鲜的病灶中发现明显的星形胶质增生，而在陈旧性病灶扩展的边缘部可见到血管周围淋巴细胞浸润。对此病的诊断标准。
Aclinicalandpathologicalstudyinfourcasesofmultiplesclerosis(MS)wasreport-ed.Therewere2malesand2females.Theywere20,26,28,and62yearsoldrespectively.Thecoursesofthediseasehadlasted32days,45days,8yearsand20yearsrespectively.Theymanlfest-edthemselvesmultiplyfocalsymptomsandsigns,inwhichvisualimpairment,motorparalysisandparapleqiaweremostcommon.Theremissionsandrelapsesoccurredonetofourtimes.Pathological-ly,thereexistedmultipledemyelinatingfocithroughoutthewhitemateroftheCNS,especialyin-vadingtheopticnerves,theopticchiasm,andthespinalcord.Demyelinatingfociinthespinalcordweremostlyseenatthelateralandposteriorcolumnsofthewhitematterwithatendencytodis-tributesymmentricaly.BothrecentandoldplaquesofMSwerepresent,varyingindegreesfromtypicaldemyelinationtonecrosis.Obviousastroglialproliferationoccurredeveninmorerecentle-sions.Incontrast,lymphocyticinfiltrationcouldbefoundinanoldlesionwithanadvancingedge.Thediagnoticcriteria,therelevantnomenclatureandsomecharacteristicsofMSwerediscussed.
出处
《中华神经科杂志》
CAS
CSCD
1996年第1期11-14,共4页
Chinese Journal of Neurology
关键词
多发性硬化
临床
病理
MultiplesclerosisDemyelinatingdiseaseNeuromyelitisoptica
