摘要
健康成年杂种犬，雌、雄分别按体重随机分４组（每组４条，雌雄各半），麻醉后十二指肠给药，正常对照组（给生理盐水１．６７ｍｌ／ｋｇ），小剂量组（给醒脑饮１．６７ｍｌ／ｋｇ，相当于５倍ＡＣＤ），大剂量组（给醒脑饮３．３３ｍｌ／ｋｇ，相当于１０倍ＡＣＤ），阳性对照组（给脑血康５ｍｌ／ｋｇ，相当于１０倍ＡＣＤ）。实验用美国产ＦＴ－０３０Ｔ型探头挂于颈总动脉，用美国产ＭＦ－２７型电磁血流量计测颈内动脉血流量；用ＣＹＳ－０．５型压力换能器测股动脉血压；针型电极刺入四肢皮下测Ⅱ导联心电图，上述指标通过多功能信号处理器输入到计算机，由计算机自动采样并处理。实验共观察脑血流量峰值（ＢＦＰ），脑血流量平均值（ＢＦＭ）．收缩压（ＳＡＰ），舒张压（ＤＡＰ），平均动脉压（ＭＡＰ），脑血管阻力（ＣＶＲ），心率（ＨＲ）和心肌耗氧指数（ＯＭＣ）八项指标。观察了给药前，给药后１０ｍｉｎ，２０ｍｉｎ，３０ｍｉｎ，９０ｍｉｎ，１２０ｍｉｎ共六个点的上述指标变化情况。结果表明，给药前后相比．醒脑饮大剂量组能明显地增加麻醉犬的脑血流量，作用持续１２０ｍｉｎ，脑血管阻力也明显降低。醒脑饮小剂量组脑血流量增加幅度较大剂量组小，存在着明显的量效关系。
Xing Nao Ying( XNY)is mainly composed of Rhizoma Acori Graminei,Radix Astragali,Radix Salviae Miltiorrhizae,etc.The effect of XNY on cerebral circulation of dogs was observed.The ani-mals were randomly allocated to 4 groups:normal control group(fed with saline 1. 67ml/kg),large dosagegroup(XNY 3. 33ml/kg),small dosage group(XNY 1. 67ml/kg)and positive control group(Nao Xue Kang5ml/kg).Blood flow and blood pressure of internal carotid artery and femoral artery were measured,andECG was also taken.Cerebral blood flow peak value,cerebral blood flow mean value,systolic blood pressure,diastolic blood pressure,mean blood pressure,cerebrovascular resistance, heart rate and myocardialoxygen consumption index were observed,These data were collected before and 10 min,20 min,30 min,90min and 120 min after medication. It was shown that the cerebral blood flow was significantly increasedand cerebrovascular resistance was significantly decreased after large dosage of XNY was given,and itseffect persisted for 2 hrs.While small dosage of the drug exerted less effect.
出处
《中药新药与临床药理》
CAS
CSCD
1996年第1期17-19,共3页
Traditional Chinese Drug Research and Clinical Pharmacology
关键词
中药
醒脑饮
药理学
脑血管循环
Xing Nao Ying/pharmacology
cerebrovascular circulation/drug effect
