摘要
目的探讨血清基质金属蛋白酶-9(MMP-9)及其抑制物-1(TIMP-1)与糖尿病视网膜病变(DR)的关系。方法采用酶联免疫吸附法对2型糖尿病患者(DM组)及正常对照组(NC组)血清MMP-9、TIMP-1、Ⅳ型胶原(CIV)水平进行检测,并按眼底结果分为三组:未合并视网膜病变(NDR)组25例,单纯型视网膜病变(SDR)组32例,增殖型视网膜病变(PDR)组18例进行组间比较。结果DM血清TIMP-1、CIV的水平是升高的且随着DR病情程度进展及病程的延长愈加明显,而MMP-9及其MMP-9/TIMP-1比值呈相应递减趋势,MMP-9水平与UAER、FBG显著负相关,TIMP-1水平与UAER、血压呈正相关。结论MMP-9及TIMP-1参与DR发生发展,检测其血清水平可反映DR严重程度。
Objective to measure the serum MMP-9 （ metalloproteinase matrix -9） TIMP-1 （ tissue inhibitor of metalloproteinase-1 ）CIV （type IV collagen ） levels to study the significance of them in the pathogenesis of diabetic retinopathy（DR） and the possible relationship among them in DR. Methods the levels of serum MMP-9 ,TIMP-1 and CIV were measured by ELISA in 20 normal controls（ NC group）and 75 cases with type 2 DM（ DM group）including 25 cases without diabetic retinopathy（ NDR group）32 cases with simple diabetic retinopathy（ SDR group）and 18 cas6s with proliferative diabetic retinopathy（ PDR group）. Results the level of TIMP-1 in PDR group was significantly higher than those in NDR and SDR groups（P 〈0. 001 ,P 〈0. 001 ） ,while the level of MMP-9 and the ratio of MMP-9/TIMP-1 in PDR group was significantly lower than those in SDR groups（ P 〈 0.05 ）. There were remarkably positive correlations between TIMP-1 and UAER,SBP,while there were significantly negative correlations between MMP-9 and UAER,FBG. Conclusions these results demonstrated that the increased serum TIMP-1 and decreased MMP-9 levels in diabetic patients seem to participate in the pathagenesis of DR and are related to the severity of DR lesion.
出处
《临床内科杂志》
CAS
2005年第9期592-594,共3页
Journal of Clinical Internal Medicine
