摘要
目的研究高同型半胱氨酸血症、叶酸和维生素B12对阿尔茨海默病(AD)的影响。方法选择89例AD患者及45例正常老年人,分为3组:AD1组(无心血管疾病)、AD2组(伴有心血管疾病)和对照组,分别应用高效液相色谱法和放射免疫法测定血浆同型半胱氨酸(hcy)、叶酸和维生素B12的含量。结果AD1组与对照组比较,hcy、叶酸和维生素B12无显著性差异。AD2组hcy、叶酸和维生素B12分别为(18.30±2.57)μmol/L、(14.30±1.18)nmol/L和(237.20±28.77)nmol/L,与其他两组比较,hcy含量显著升高,叶酸含量显著降低,维生素B12含量无显著性差异。结论高同型半胱氨酸血症与AD的发病无关,与AD的严重程度有关。血清叶酸的降低是导致AD患者高同型半胱氨酸血症的重要因素。维生素B12与AD患者高同型半胱氨酸血症的发生无关。
Objective To Alzheimer＇s disease （AD）. Methods study effect of hyperhomoeysteinemia, folate and vitamin B12 on Chose 89 AD patients and 45 normal elder people, and divided into three groups, including AD1 group without cardiovascular disease, AD2 group with cardiovascular disease and control group. Investigate plasma level of hcy, folate and vitamin B12 with high performance liquid chromatography and radioimmunoassay differently. Results Levels of hcy, folate and vitamin Bl2 in ADI group were no level is （ 18.30 ± 2.57） μmol/L, significant difference compared folate level is （ 14.30 ± 1.18 ） to control group. In AD2 group, hey nmol/L, and vitamin B12 is （237.20 ± 28.77） nmol/L. Hey level is significant high in AD2 group as well as folate level is significant low compared with the other groups. Vitamin B12 is no obvious difference in AD2 group compared to the other groups Conclusion Hyperhomocysteinemia bears no relations to occurrence of AD, but has an effect on severity of AD. The decrease of serum folate level is an important factor to hyperhomoeysteinemia in AD, but vitamin B12 has no effect on it.
出处
《医药论坛杂志》
2005年第17期42-43,46,共3页
Journal of Medical Forum
