摘要
本研究观察了大黄虫丸对高脂血症患者及家兔实验性高脂血症的降脂作用。结果表明:大黄虫丸能降低高脂血症患者血清甘油三酯,总胆固醇,同时能使全血比粘度、全血还原粘度和纤维蛋白原水平下降。降低家兔实验性高脂血症血清总胆固醇、甘油三酯、β-脂蛋白的含量及全血比粘度、血浆比粘度。对高密度脂蛋白及其亚类的影响不明显。上述结果说明大黄虫丸对防治动脉粥样硬化可能有一定作用,对缺血性心脑血管疾病的防治有一定的意义。
Experimental and clinical researches were done for the purpose of that to treat the hyperlipemia with Dahuang Zhechong Wan(DHZCW).The patients of primary hypertipemia were divided into two groups.One group was treated with DHZCW,the other with inositol nicotinate as control.DHZCW could reduce the serum total cholesterol(0.05<P<0.2),triglyceride(P<0.05),the blood viscosity(P< 0.01),reductive viscosity(P<0.001)and fibrinogen(0.05<P<0.2).No significant change of the other item of hemorrheology,HDL-c and the subffaction were observed.No significant differential effect between those two groups. The experimental hyperlipidemic model was made by feeding cholesterol and axungia on rabbits.The results showed that DHZCW could reduce the scrum total cholesterol(P<0.05), triglyceride(P<0.05),β-LP(P<0.01),the blood viscosity(P<0.05)and plasma viscosity(P<0.05),but no significant effect On HDL-c and its subfraction.ESR,index of erythrocytic deformation and hematocrit. DHZCW could change the viscosity of blood of hyperlipemia and reduce the total cholesterol, triglyceride and fibrinogen of the blood,It might halve some beneficial effects on atherosclerosis and prevent ischemic cardiovascular and cerebrovascular diseases.
出处
《中西医结合杂志》
CSCD
北大核心
1989年第10期589-592,580,共4页
