普罗布考治疗46例糖尿病肾病的疗效观察被引量：1

Observation of the therapeutic effect of probucol on 46 cases of diabetic nephropathy

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摘要目的评估普罗布考(probucol)延缓糖尿病肾病(diabetic nephropathy,DN)进展的疗效。方法将102例临床出现白蛋白尿(尿微量白蛋白>1.9 mg/dl)的2型糖尿病患者,在常规药物治疗的基础上,分成普罗布考组(普罗布考500 mg/d,n=51)和对照组(n=51),随访6个月检测患者血压、血脂(TB、TG、LDL-c、HDL-c)、肾功(s-Cr、BUN、cys-c)、尿蛋白(尿微量白蛋白、24 h尿蛋白定量)、糖化血红蛋白(HbA1c)、超敏C反应蛋白(hs-CRP)、肝功(AST、ALT、GGT)并作统计学分析。结果随访期间,普罗布考治疗组失访5例,对照组失访3例。①普罗布考组治疗后血脂(TC、TG、LDL-c)、cys-c、hs-CRP均较治疗前和对照组均明显下降(P<0.05),并且肾功(s-Cr、BUN)、尿微量白蛋白、24 h尿蛋白定量的增加值普罗布考组明显低于对照组(P<0.05)。②在ARB/ACEI类药物(n=48)用药的基础上,普罗布考治疗更能降低患者cys-c、hs-CRP、24 h尿蛋白定量以及尿微量白蛋白增加水平(P<0.05)。结论普罗布考可以改善糖尿病肾病患者尿蛋白以及肾功能情况,对DN进展具有延缓作用,若联合使用ARB/ACEI类药物,对糖尿病肾病的防治会产生协同作用。 Objective To evaluate the therapeutic effect of probucol on delaying the progression of diabetic nephropathy（DN）.Methods One-hundred-and-two type II diabetes patients with albuminuria（microalbuminuria 1.9 mg/dl） were divided in a probucol group（500 mg/d,n=51） and a control group（n=51） based on the routine drug treatment.A follow-up survey was carried out for 6 months,in which the blood pressure,blood lipid（TC,TG,LDL-C and HDL-c）,renal function（s-Cr,BUN and cys-c）,urine protein（microalbuminuria and 24 h urine protein）,glycosylated hemoglobin（HbA1c）,hypersensitive C-reactive protein（hs-CRP）,and liver function（AST,ALT and GGT） were detected.Statistical analyses were also conducted.Results During the 6-month follow-up,the data of 5 patients of probucol group and 3 patients of control group were lost.The blood lipid（TC,TG and LDL-c）,cys-c and hs-CRP of the probucol group after treatment were significantly lower than those of the probucol group before treatment and the control group（P0.05）.The increases of s-Cr,BUN,microalbuminuria and 24-h urine protein in the probucol group were significantly lower than those in the control group（P0.05）.Based on the administration of angiotensin converting enzyme inhibitor/angiotensin receptor blocker（ARB/ACEI） drugs（n=48）,probucol could suppress the increases of cys-c,hs-CRP,microalbuminuria and 24-h urine protein（P0.05）.Conclusion Probucol can reduce the urine protein content and improve the renal function of DN patients,thus delaying the progression of DN.Besides,probucol has a synergic effect with ARB/ACEI drugs on the prevention and treatment of DN.

作者梁瑞凯魏平

机构地区第三军医大学西南医院内分泌科

出处《第三军医大学学报》 CAS CSCD 北大核心 2011年第8期849-852,共4页 Journal of Third Military Medical University

关键词普罗布考糖尿病肾病尿微量白蛋白 24H尿蛋白定量 probucol diabetic nephropathy microalbuminuria 24-h urine protein

分类号 R587.205 [医药卫生—内分泌] R692.05 [医药卫生—泌尿科学]

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