摘要
内毒素制造的家兔全身性 shwartzman 反应模型,肝线粒体 H^+-ATP 合酶活性下降,而热毒清组此酶活性正常,两组间有显著差异(P<0.05)。提示热毒清注射液具有保护线粒体 H^+-ATP 合酶的作用。
To observe the effect of Re-Du-Qing on the toxic effect of endotoxin,the rabbit model of general Sbwartzman reaction was made by injection of endotoxin into ear vein and the H^+-ATP synthase activities of rabbit liver mitochondria were measured.The results showed that the H^+-ATP synthase activity of endotoxin group was significantly lower than that of the normal group and group which had been simultaneously injected Re-Du-Qing(P<0.05).The tevel of H^+-ATP synthase activity was almost raised to normal value,when Re-Du-Qing or dexamethasone was injected simultaneously with endotoxin respectively.It suggested that Re-Du-Qing was able to alleviate the nocuous effect of endotoxin on H^+-ATP synthase activity in the mitochondria of rabbit liver cells.
出处
《中西医结合杂志》
CAS
CSCD
北大核心
1989年第10期607-608,共2页
基金
国家自然科学基金资助课题
