摘要
用5mmol／LPARP抑制剂苯甲酸胺处理经c－Ha－T24－ras活化癌基因转染得到的转化细胞系，处理4周后发现转化细胞系的某些细胞生物学特性发生了改变，呈现出正常细胞的某些特性．伴随这一现象，检测到细胞中整合的外源T24－ras基因发生了丢失．
A transformant line obtained by transfection of NIH3T3 cells with c-Ha-T24-ras gene was treated with 5mmol / L benzamide, an inhibitor of PARP cnzyme for 4 weeks. Some changes in cellular properties of the transformant line werc obscrved. Concomitant with these changes was the deletion of the exogenous c-Ha-T24-ras which had been integrated into genomic DNA of recipient cells.
出处
《遗传》
CAS
CSCD
北大核心
1996年第3期6-8,共3页
Hereditas（Beijing)
基金
国家自然科学基金
关键词
转化细胞逆转
RAS癌基因
基因丢失
肿瘤
Poly (ADP-ribosyl) ation,Transformed cell reversion, ras oncogene, Deletion
