摘要
本文采用双波长分光光度法同时测定栓剂中甲硝唑、诺氟沙星的含量；甲硝唑的测定波长为３１３．０ｎｍ，参比波长为２６１．５ｎｍ，诺氟沙星的测定波长为２８３．５ｎｍ，参比波长为３４０．５ｎｍ，甲硝唑的平均回４文率为１００．７４％，ＲＳＤ为０．７１％；诺氟沙星的平均回收率为１００．０５％，ＲＳＤ为０．６５％。该法快速、简便，结果准确，适用于该制剂质量控制。
dual wavelength spectrophotometry was described for determination of metronidazole and norfloxacin insuppository. The sample wavelength was 313 nm and the reference wavelength was 261nm for metronidazole. Thesample wavelength was 283nm and the reference wavelength was 340nm for norfloxacin. The recoveries of metro-nidazole and norfloxacin were 100. 71 % ± 0. 71 % and 100. 05% ± 0. 65% respectively. This method is simple. It issuitable for quality control of suppositories containing metronidazole and norfloxacin.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1996年第1期22-24,共3页
Chinese Journal of Hospital Pharmacy
关键词
双波长
分光光度法
甲硝唑
诺氟沙星
dual wavelength spectrophotometry,metronidazole,norfloxacin
