摘要
测定了１２种药物对临床分离的３０株厌氧菌和３株标准菌株的ＭＩＣ，确定甲哨唑和ｃｌａｒｉｔｈｒｏｍｙｃｉｎ对革兰氏阴性厌氧菌的抗菌活性最强，其ＭＩＣ为０．５～１μｇ／ｍｌ．其次为大环内酯９４１和国产ｃｌａｒｉｔｈｒｏｍｙｃｉｎ（４μｇ／ｍｌ）及林可霉素和红霉素（８μｇ／ｍｌ），它们对于革兰氏阳性厌氧菌（包括梭菌）及消化链球菌也有相当的活性，而环丙氟啶酸、依诺沙星、头孢克罗、环丙沙星等抗厌氧菌拟杆菌活性较低；其ＭＩＣ为１６～６４μｇ／ｍｌ。
MICs of 12 antimicrobial agents against 33 clinical isolates of anaerobes were determined. Results showed that metronidazole and clarithromycin had the strongest activities against Gram-negative anaerobes (MICs range 0.5～1.0μg/ml)and macrolide antibiotic 941, domestic clarithromycin, lincomycin and erythromycin followed(MICs 8μg/ml). These agents showed certain activities against Gram-positive anaerobes (including Closatridium spp. )and Peptostreptococcus(MICs range 0. 25～8μg/ml).But antibiotic activities of ciprenoxacin, enoxacin, cefaclor and ciprofloxacin against anaerobic bacteroides were weaker, their MICs range from 16 to 64μg/ml.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
1996年第1期36-39,共4页
Chinese Journal of Antibiotics
关键词
抑菌
厌氧菌
药敏试验
最低抑菌浓度
抗菌药
Anaerobes,Sensitivity test, Minimal inhibiton concentration (MIC)
