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IL-7对中国HIV/AIDS患者病程的影响 被引量：1

Effects of interleukin-7 on disease progression in HIV/AIDS patients from China
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摘要 目的了解IL7对中国HIVAIDS患者病程的影响。方法应用超敏感酶免法对66例中国HIVAIDS感染者及8例健康对照者血浆IL7水平进行定量检测,分析其与CD4+T细胞绝对值、血浆病毒载量及HIV表型的相关性;并且在体外研究rhIL7对人PBMC中T淋巴细胞增殖及CXCR4表达的影响。结果中国HIVAIDS患者血浆IL7水平高于健康对照(P<0.05),与CD4+T细胞绝对值负相关(P<0.01),与血浆病毒载量正相关(P<0.05)。rhIL7可在体外促进T淋巴细胞增殖反应及CXCR4表达。结论中国HIVAIDS患者血浆IL7水平升高,且与疾病进展密切相关,可作为疾病进展的相关标志之一。 Objective To investigate the effects of IL-7 on disease progression in HIV/AIDS patients. Methods Plasma IL-7 levels of 66 HIV/AIDS patients and 8 healthy controls were determined by an ultrasensitive ELISA, its relations with CD4^＋ T cells, plasma viral load and HIV phenotypes were analysed. T lymphocyte proliferation and CXCR4 expression of peripheral blood mononuclear cells from healthy donors were cocultured with rhIL-7, followed by flow cytometry. Results Significant high level IL-7 was found in HIV/AIDS patients（ P〈0.05）, IL-7 level was negatively correlated with CD^4＋ T cell absolute count（P〈0.01） and positively correlated with plasma viral load （P〈0.05） . Conclusion rhIL-7 may induce T lymphocyte proliferation and up-regulate CXCR4 exoression in vitro, so IL-7 plasma level may be function as a potential marker of HIV disease progression.
作者 王琪 尚红 姜拥军 王亚男 韩晓旭 张子宁 刘静
机构地区 中国医科大学附属第一医院艾滋病研究所
出处 《中华微生物学和免疫学杂志》 CAS CSCD 北大核心 2005年第8期667-671,共5页 Chinese Journal of Microbiology and Immunology
基金 国家十五科技攻关课题(2004BA719A12)
关键词 人类免疫缺陷病毒-1(HIV-1) 白细胞介素-7(IL-7) HIV/AIDS患者 IL-7 中国 T淋巴细胞增殖反应 病程 血浆病毒载量 CD4^+T细胞 CD^+T细胞 Human immunodeficiency virus-1 （HIV-1） Interleukin-7 （IL-7）
分类号 R512.91 [医药卫生—内科学] R739.502 [医药卫生—肿瘤]
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参考文献12

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共引文献7

同被引文献23

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中华微生物学和免疫学杂志
2005年 第8期

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