摘要
胰岛素样生长因子-I(IGF-Ⅰ)是属于胰岛素家族的一种多肽,它与特异性受体结合发挥生理功能。IGF-Ⅰ通过提高心肌收缩性和促进组织重塑改善心肌梗死后心功能。此外还抑制心肌细胞凋亡,促进心肌细胞增殖和肥大、增强心脏功能、维持心脏结构。这篇综述着重于IGF-Ⅰ调节心脏生长和心功能的作用以及IGF-Ⅰ在冠心病中的作用。
Insulin-like growth factor Ⅰ （ IGF-Ⅰ） belongs to the insulin family of peptides and acts as a growth factor in heart through conjugating specific receptors. IGF-Ⅰ improves cardiac function after myocardial infarction by stimulating contractility and promoting tissue remodeling. Furthermore, IGF-Ⅰ suppresses apoptosis of cardiomyocytes, activates myocytes proliferation, induces myocytes hypertrophy, improves cardiac function,preserves myocardial structure in animals and patients . The present review will emphasize the role of IGF-Ⅰ in the regulation of cardiac growth and function,and the role of IGF-Ⅰ in the coronary heart disease.
出处
《心血管病学进展》
CAS
2005年第5期505-507,共3页
Advances in Cardiovascular Diseases
关键词
胰岛素样生长因子-Ⅰ
凋亡
冠心病
Insulin-like growth factor Ⅰ
Apoptosis
Coronary heart disease
