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中药抗肝纤维化治疗对蛋白激酶C表达的影响 被引量:4

Expression of PKC in rat hepatic fibrosis and the effect of Dan-shao-hua-xian Capsule on its expression pattern
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摘要 观察了四氯化碳(CCl4)中毒性肝纤维化大鼠肝脏组织蛋白激酶C(PKC)α表达及其在中药复方丹芍化纤胶囊抗肝纤维化治疗后的变化. 一、材料与方法 1.材料:(1)药品和主要试剂:丹芍化纤胶囊由贵阳制药厂生产,实验时取胶囊内容物研磨成粉末,用蒸馏水稀释至所需浓度.
出处 《中华肝脏病杂志》 CAS CSCD 北大核心 2005年第9期707-708,共2页 Chinese Journal of Hepatology
基金 贵州省高层次人才经费(20003-2)贵州省中药现代化项目经费(2004-09)
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参考文献5

  • 1Ming LC, Chang QY. The basic study and clinical research on hepatic fibrosis. Second ed. Los Angeles: First Jumbo Publishing Co.,2002. 20-35.
  • 2Gallet C, Blaie S, Levy-Toledano S, et al. Epidermal-growth-factor receptor and metalloproteinases mediate thromboxane A2 dependent extracellular-signal-regulated kinase activation. Biochem J, 2003,371(Pt 3):733-742.
  • 3Pinzani M, Marra F, Carloni V. Signal transduction in hepatic stellate cells. Liver, 1998, 18: 2-13.
  • 4Bataller R, Gasull X, Gines P, et al. In vitro and in vivo activation of rat hepatic stellate cells results in de novo expression of L-type voltage-operated calcium channels. Hepatology, 2001, 33: 956-962.
  • 5Di Sario A, Svegliati Baroni G, Bendia E, et al. Intracellula r pH regulation and Na+/H+ exchange activity in human hepatic stellate cells: effect of platelet-derived growth factor, insulin-like growth factor 1 and insulin. J Hepatol, 2001, 34: 378-385.

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