摘要
检测３１例肾移植急性排斥患者血中ＯＫＴ_３水平，发现经ＯＫＴ_３治疗有效患者明显低于无效者（Ｐ＜０．００５），体外实验证实有效患者血清有致Ｔ细胞ＣＤ_３抗原调变作用；这一状况与ＯＫＴ_３在含人血清淋巴细胞培养基中所致ＣＤ_３调变相符。去除残留ＯＫＴ_３，有效患者在含不致ＣＤ_３调变浓度ＯＫＴ_３存在下仍有上述效果。提示有效患者体内存有促进ＣＤ_３调变的影响因素。推测这一因素可能与抗鼠抗体有关。
The plasma level of OKT_3 was detected in 31 patients showing acute rejection after renal transplantation. The concentration of OKT_3 was significantly lower in patients on whom OKT_3 treatment was effective than in those OKT_3 was ineffective (P<0.005). In an in vitro experiment, the serum obtained from the OKT_3-effective patients modulated the T-lymphocyte antigen CD_3, which was consistent with the modulation of CD_3 after administration of OKT_3, in the culture-medium containing human serum was observed after extraction of OKT_3 the effective serum still modulated CD_3 in the presence of a low concentration of OKT_3 which alone was demonstrated to be ineffective on CD_3 modulation. These data suggest that there must be present some factors in the effective serum which could enhance the modulating effect of OKT_3 on CD_3. A human antimice antibody was supposed to be involved in this action.
出处
《上海第二医科大学学报》
CSCD
1996年第1期11-13,共3页
Acta Universitatis Medicinalis Secondae Shanghai
