摘要
对２６名健康男性国人ｐｏ６０ｍｇ尼莫地平普通片后药代动力学进行研究．Ｃｍａｘ，Ｔｍａｘ，ｔ１／２，ＭＲＴ和ＡＵＣ分别为６９±３４μｇ·Ｌ－１，１．１±０．３ｈ，２．２±０．６ｈ．３３±０９ｈ和１８６±７３μｇ·ｈ·Ｌ－１．ＡＵＣ和Ｃｍａｘ有较大的个体差异．对ＡＵＣ值作频数和机率图分析结果表明存在双态分布．提示尼莫地平药代动力学存在多态性．根据ＡＵＣ值大小，将受试者分成快代谢型和慢代谢型两类，结果显示受试者大多（２４／２６）属于快代谢型（ＡＵＣ＞３００μｇ·ｈ·Ｌ－１）．
The pharmacokinetics of nimodipine (Nim) tablet in 26 healthy Chinese males was studied after an oral dose of 60 mg. Pharmacokinetic parameters for T max , C max , t 1/2 , MRT and AUC were estimated as follows. T max 1 1±0 3 h, C max 69±34 μg·L -1 , t 1/2 2 2±0 6 h, MRT 3 3±0 9 h, and AUC 186±74 μg·h·L -1 . There were large intersubject variabilities in both AUC and C max . When individual AUC values were cumulated and the frequency histogram and probit analysis were performed, a bimodal distribution was observed. The result indicated the hypothesis of the existence of a polymorphism concerning Nim disposition kinetics. The individuals were grouped as fast and slow metabolizers according to the AUC values. High frequency (24/26) of fast metabolizers was found (AUC>300 μg·L -1 ).
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
1996年第1期25-27,共3页
Chinese Journal of Pharmacology and Toxicology
