摘要
以硫脲和丙二酸二乙酯为初始原料,经环合等多步反应合成4,6-二甲氧基-甲砜基嘧啶,间硝基邻甲基苯胺经重氮化得到重氮产物间硝基邻甲基苯酚.4,6-二甲氧基-甲砜基嘧啶和间硝基邻甲基苯酚反应得到2-(苄基-6-硝基-苯氧基)-4,’6’-二甲氧基嘧啶,再经溴化反应得到2-(苄基溴-6-硝基-苯氧基)-4,’6’-二甲氧基嘧啶,其与六个取代基苯胺反应,分别得到六个2-(4,’6’-二甲氧基)嘧啶氧基-6-硝基-N-芳基苄胺衍生物,产物经质谱和核磁氢谱检测确定.
2-Methanesulfonyl-4,6-dimethoxypyrimidine was gained using sulphur urea and diethyl malonate as raw materials. 2-methyl-3-nitryl aniline was diazotized gaining 2-methyl-3-nitryl- phenol. 2-（benzyl-6-nitryl-phenoxyl）-4＇, 6＇-dimethoxy-pyrimide was synthesized while 2- methanesulfonyl-4,6- dimethoxypyrimidine was added to 2-methyl-3-nitryl-phenol. 2-（benzyl-6- nitryl-phenoxyl ）-4＇ , 6 ＇-dimeth-oxy-pyrimide was bromized gaining 2- （benzylbromine-6-nitrylphenoxyl ）-4 ＇ , 6 ＇-dimethoxy-pyrimide. 2-（ 4 ＇ , 6 ＇-dimethoxy ）-pyrimidyloxy-6-nitryl-N-arylbenzylamine derivatives were prepared by 2-（ benzylbr-omine-6-nitryl-phenoxyl ）-4 ＇ , 6 ＇ dimethoxy-pyrimide and anilines. The structures of productions were indentified by mass spectrograph and 1H NMR spectrum data.
出处
《浙江工业大学学报》
CAS
2005年第4期372-375,共4页
Journal of Zhejiang University of Technology
基金
浙江省科学技术厅中德国际合作资助项目(021106401)
