摘要
目的:应用电子束CT(EBT)心脏扫描,了解受检者冠脉病变的发生情况,分析冠脉病变发生的危险因素.方法:107例受试者行心脏EBT扫描,计算冠脉钙化发生率、钙化积分、冠脉狭窄支数和软斑数,同时收集血糖、糖化血红蛋白(HbA1c)、血脂等相关临床信息,进行冠脉病变危险因素的分析.结果:糖耐量受损组、糖尿病组、高血压病组冠脉钙化发生率较正常对照组显著升高(93%,96%,90%vs56%,P＜0.01).钙化积分有明显升高趋势,但统计学检验无显著性差异.冠脉狭窄支数和软斑数显著增加(2.2±2.0,3.0±1.9,2.2±1.1vs0.5±1.3,P＜0.05和2.5±2.4,2.9±1.8,2.3±1.8vs0.5±1.2,P＜0.05).Logistic回归分析,发现糖尿病、高血压两因素对冠脉病变的影响有统计学意义(P＜0.05),OR值分别为7.514(95%可信区间0.885～63.778)、6.653(95%可信区间1.344～32.928).结论:糖尿病、高血压病患者发生冠脉病变有高度的危险性.
AIM： To assess the risk of coronary artery damage by electron beam tomography （EBT） in population. METHODS： A total of 107 subjects aged 36 -78 years underwent cardiac EBT, with coronary artery calcification （ CAC ） incidence, calcium scoring, stenosed arteries and soft plaques calculated. Laboratory evaluation included measurement of 75 g oral glucose tolerance test （OGTr） , HbAlc, triglyceride, total cholesterol. Logistic regression analysis was taken to assess the risk for coronary artery damage. RESULTS ： The incidences of CAC in IGT （ 93% ）, diabetes （ 96% ） and hypertension （ 90% ） groups were significantly （P 〈0.01 ） higher than that in the normal（56% ）. The scores of CAC in IGT, diabetes and CHD groups were also higher though they did not quite reach statistical significance because of our cohort size. The numbers of stenosed arteries and soft plaques were more than those in the normal （2.2±2.0, 3.0±1.9,2.2±1.1vs0.5＋1.3,P〈0.05 and 2.5±2.4,2.9±1.8,2.3±1.8 vs 0.5 ＋ 1.2, P 〈 0.05 ）. The result of logistic regression analysis ： OR of diabetes group was 7.514 （ 95 % CI ： 0. 885～63. 778 ） and OR of hypertension group was 6. 653 （ 95% CI ： 1. 344～32. 928 ）. CONCLUSION： The diabetes and hypertension patients have higher risk for coronary artery damage.
出处
《心脏杂志》
CAS
2005年第4期380-382,共3页
Chinese Heart Journal
关键词
冠状动脉疾病
危险性分析
冠脉钙化
糖尿病
coronary disease
risk assessment
coronary artery damage
diabets mellitus
