摘要
目的:健康人外周血中前体CD34+细胞数目很少,但在急性缺血时,这些细胞可以从骨髓动员到外周血。研究发现,有心血管危险因素的患者,外周血CD34+细胞数目是减少的。然而,有心血管事件危险因素的患者,急性心肌梗死是否能促进CD34+细胞的动员,目前尚不完全清楚。方法:42例心血管事件危险因素患者被分成两组:急性心肌梗死组20例,无冠状动脉粥样硬化性心脏病组22例。同时,没有冠心病及任何心血管病危险因素的16例自愿者入选为健康对照组。流式细胞仪分析外周血CD34+细胞数目。结果:急性心肌梗死组,外周血CD34+细胞的数目为(1.915±0.667)/μl,与健康对照组(1.925±0.629)/μl值比较,P=0.963。无冠状动脉粥样硬化性心脏病组,外周血CD34+细胞的数目为(1.804±0.605)/μl。在心肌梗死组与无冠心病组间比较,外周血CD34+细胞的数目无明显不同(P=0.575)。而且,患者并存心血管危险因素的多少与外周血中CD34+细胞水平似乎成反向相关。结论:有心血管事件危险因素患者,发生急性心肌梗死后外周血前体CD34+细胞未发现增加。由此提示心血管病危险因素可能抑制急性缺血诱导的前体CD34+细胞的动员,且与危险因素多少相关。
AIM： Evidence demonstrates that the circulating CD34^＋ progenitor cells in healthy people are very few; however, they can be mobilized into peripheral blood from bone marrow （ BM ） in response to acute myocardial ischemic events and contribute to regeneration of myocardial tissues. Studies have shown that various cardiovascular risk factors can influence mobilization of CD34^＋ cells. This study was conducted to investigate the change in circulating CD34^＋ cells of patients with cardiovascular risk factors during acute myocardial infarction （AMI）. METHODS： 42 patients with cardiovascular risk factors were classifted into 2 groups： patients with acute myocardial infarction （ n = 20 ） and patients without coronary artery disease （ n = 22）. 16 volunteers without any evidence of cardiovascular risk factors and coronary artery diseases were chosen as healthy controls. The number of CD34^＋ cells in peripheral blood （ PB） was analyzed by flow cytometer. RESULTS ：The number of circulating CD34^＋ cells was （ 1. 915 ± 0. 667 ）/μl in AMI patients as against （ 1. 925 ± 0. 629 ）/μl in healthy controls （ P = 0. 963 ） and （ 1. 804± 0. 605 ）/μl in patients without CAD. There was no significant difference between patients with AMI and patients without CAD （ P = 0.575 ）. Moreover, an inverse correlation between circulating CD34^＋ progenitor cells and the number of risk factors was detected. CONCLUSION： Circulating CD34^＋ progenitor cells do not increase in AMI patients with cardiovascular risk factors. It is suggested that acute-ischemia-induced mobilization of CD34^＋ precursor cells may be inhibited by cardiovascular risk factors, which iscorrelated with the number of risk factors.
出处
《心脏杂志》
CAS
2005年第4期367-370,共4页
Chinese Heart Journal
基金
国家自然科学基金资助项目
批准号:3037059
