摘要
目的观察国产盐酸莫索尼定对麻醉大鼠血流动力学的影响。方法采用麻醉Wistar大鼠动脉插管法,测定其血流动力学指标。结果给药后,HR、SBP轻度下降(P>0.05);DBP明显下降(P<0.01)的同时,±dp/dtmax,tdp/dtmax、Vpm及Vmax明显降低(P<0.01),且呈剂量依赖性。结论莫索尼定对心肌收缩性与舒张性均有明显的抑制作用;其降压作用与外周阻力下降有关。
Aim To investigate effects of moxonidine on hemodynamics in anesthetized rats. Methods The indexes of hemodynamics were examined by catheterization of arteries in anesthetized Wistar rats. Results DBP, ＋ dp/dtmax,- dp/dtmax, t-dp/dtmax Vpm and Vmax were significantly declined in dose-dependent manner after administration, but HR and SBP didn＇t change significantly. Conclusion These resultsshowed that antihypertensive effects of moxonidine were related to inhibition of systolic and diastolic functions of myocardium. Furthermore, the antihypertensive effects of moxonidine were associated with reduction of peripheral vascular resistance.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2005年第8期1010-1013,共4页
Chinese Pharmacological Bulletin
基金
江苏省科技攻关资助项目(NoBE96049)
关键词
莫索尼定
血压
血流动力学
可乐定
moxonidine
blood pressure
hemodynamics
clonidine
