摘要
目的评价组织多肽抗原(TPA)在鼻咽癌诊断和监测中的临床价值。方法鼻咽癌病人28例,健康对照组10例,应用酶联免疫吸附试验(ELISA)检测TPA、EAIgA、VCAIgA三项指标并比较分析其检测结果。结果鼻咽癌组三项指标均明显高于健康对照组(P<0.05)。TPA与鼻咽癌分期、淋巴结转移和远处转移有关,病人经放射治疗后TPA值下降,TPA值一定程度上可以反映鼻咽癌转归。结论TPA和EAIgA、VCAIgA联合应用对鼻咽癌的诊治有一定价值。
Objective To study the clinical value of tissue polypeptide antigen （TPA） in diagnosis and monitoring the course of patients with nasopharyngeal carcinoma. Methods The serum levels of TPA, EA-IgA, VCA-IgA were determined by enzymelinked immurno-sorbent assay in the 28 patients with nasopharyngeal carcinoma and 10 healthy adults. Results The level of three tumor markers in nasopharyngeal carcinoma group was higher than that of the control group. TPA was well associated with the TNM staging, lymph node and remote metastases. TPA decreased after radiotherapy. TPA value was correlated with the regression or progression of the disease. Conclusion The combined application of the TPA together with the EA-IgA and VCA-IgA may be helpful to the diagnosis and treatment of nasopharyngeal carcinoma.
出处
《中国耳鼻咽喉颅底外科杂志》
CAS
2005年第4期263-265,共3页
Chinese Journal of Otorhinolaryngology-skull Base Surgery
