摘要
目的:探讨AFP、TPA、TPS、CA199和CEA对原发性肝癌(PHC)的临床应用价值。方法:采用酶联免疫吸附法,分别测定85例PHC、19例肝转移癌、35例肝硬化、22例慢性肝炎患者和50例健康查体者血清AFP、TPA、TPS、CA199和CEA水平,并应用ROC曲线分析各项标志物对肝癌的诊断价值。结果:AFP对PHC的诊断价值最高;TPA、TPS和CA199在PHC和肝转移癌患者血清中均有高水平表达;CEA对PHC无诊断价值,但对肝转移癌具有一定的诊断价值。AFP联合检测TPA、TPS或CA199可以提高PHC的诊断敏感性,但特异性有所下降。结论:AFP联合CEA可以用于PHC与肝转移癌的鉴别,联合TPA或TPS有助于早期发现PHC的远处转移,联合TPS和CA199适合于无明显症状的门诊患者和PHC高危人群的筛查。
Objectives To evaluate the clinical value of some tumor markers, including AFP, TPA,TPS,CA199 and CEA in the diagnosis of primary hepatic cancer . Methods： The serum levels of AFP,TPA,TPS,CA199 and CEA were measured by ELISA in 8.5 patients with PHC, 19 with secondary liver metastasis, 35 of liver cirrhosis, 22 of chronic hepatitis and 50 healthy examinations. The diagnostic values were analyzed using ROC curve. Results：The diagnostic value of AFP for PHC was the highest. Serum TPA,TPS and CA199 levels were higher both in PHC and secondary liver metastasis patients. CEA is valuable in the diagnosis of secondary liver metastasis, but not in that of PHC, AFP, Combined with TPA,TPS or CA199 increased the sensitivity, but the specificity reduced. Conclusion： AFP combined with CEA could he used for the differentiation hetween PHC and secondary liver metastasis, with TPA or TPS could help the early diagnosis of PHC with metastasis, with TPS and CA199 was suitable to be used as an surveying tool for symptomless patients, especially for high risk PHC patients.
出处
《陕西医学杂志》
CAS
北大核心
2006年第2期192-195,共4页
Shaanxi Medical Journal
