摘要
以苯并氧化呋咱为原料,通过Beirut反应合成了卡巴多的关键中间体2-甲醛肟基喹喔啉-N,N’-二氧化物,在甲醛存在下酸水解为2-甲酰基喹喔啉-N,N’-二氧化物,后者再与肼基甲酸甲酯缩合生成卡巴多.产物经高分辨质谱、核磁共振鉴证.
Starting from benzofurazan oxide （BFO）, 2-formaldoximyl-quinoxaline-N,N＇-dioxide （oxime） is synthesized through Beirut reaction, which is the key step in the synthesis process of Carbadox, an excellent antivirus somatotropic agent. Oxime is acid-hydrolyzed to 2-formyl-quinoxaline-N,N＇-dioxide in the presence of formaldehyde, the latter then condensed with methyl-hydrozinylformate to produce the desired Carbadox. The product is confirmed by mass spectrum（MS） and nuclear magnetic resonance （NMR）.
出处
《西南民族大学学报（自然科学版）》
CAS
2005年第5期721-723,共3页
Journal of Southwest Minzu University(Natural Science Edition)
