阿托伐他汀对冠状动脉介入术后C反应蛋白的影响被引量：8

Valuation of plasma levels of C-reactive protein after percutaneous coronary intervention and effection of atorvastatin

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摘要目的:测定经皮腔内冠状动脉介入术(PCI)后C-反应蛋白(CRP)的水平并评价阿托伐他汀对其影响。方法:连续选择因冠状动脉狭窄性病变行PCI的冠心病患者60例,随机分为治疗组和对照组,治疗组在对照组治疗的基础上给予阿托伐他汀20mg,qd,术前及术后2d和3周分别测外周动脉血清CRP。结果:术前、术后2d及术后3周,治疗组CRP水平分别为(9.03±0.59)、(23.5±0.71)及(12.8±0.47)mg/L,对照组则分别为(8.8±0.62)、(21.2±0.56)及(19.6±0.53)mg/L,两组术后3周比较,差异有统计学意义(P<0.01);术前、术后2d及术后3周治疗组CK-MB分别为(11.9±3.3)、(14.6±3.2)、(16.0±2.8)IU/L,对照组为(12.1±3.4)、(14.3±2.6)、(15.6±3.0)IU/L,两组术后CK-MB均无升高,两组术前、术后相比较,均P>0.05。结论:PCI后血清CRP水平升高,阿托伐他汀可明显控制血浆炎症因子,有利于动脉粥样硬化斑块的稳定。 Objective：To investigate the plasma level of C-reactive protein （CRP） after percutaneous coronary intervention（PCI） and the effect ofatorvastatin treatment. Method： The population studied consistcd of 60 consecutive patients with stable angina who underwent elected PCI for stenotic lesions of the coronary artery. Patients were randomly assigned to treatment group or control group. Blood samples for measurement of CRP were ob tained before procedure, follwed 2 days and 3 weeks after procedure. Result：CRP levels of treament group before procedure, and followed 2 days, 3 weeks were respectively （9. 03±0.59）, （23.5±0. 71）,（12.8±0.47）mg/L, contrast group were （8. 8±0. 62） , （21.2±0. 56）, （19. 6±0. 53）mg/L. Conclusion：Plasma level of CRP increased after PCI ,while atorvastatin treatment decreased plasma level of inflammatory factor, so it may benefit to stabilization of atherosclerotic plaque.

作者徐广马林英忠王风袁军刘伶伍广伟

机构地区广西自治区人民医院心内科

出处《临床心血管病杂志》 CAS CSCD 北大核心 2005年第8期488-489,共2页 Journal of Clinical Cardiology

关键词血管成形术经腔经皮冠状动脉 C反应蛋白阿托伐他汀 Angioplasty,transluminal, percutaneous coronary C reactive protein Atorvastatin

分类号 R654.3 [医药卫生—外科学]

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