摘要
儿科临床中常可遇到一些长期喂养困难的小儿,没有任何医学上的原因可以解释其食欲不良.近来已发现消化道功能与消化道内分泌水平有关,本文研究了12例厌食小儿的血胃泌素与生长抑素水平。12例9月～4.5岁小儿的体重和身高明显低于同龄同性别小儿,但无任何明显的疾病存在。取晨空腹周围血测基础胃泌素与生长抑素水平,进食后1h再测其变化。血胃泌素与生长抑素均采用放免法测定。结果示厌食小儿基础生长抑素水平2倍于对照组,基础胃泌素水平与对照组无差别。进食1h后生长抑素水平从餐前的237.27±31.08降至172.32±23.48ng/L,胃泌素水平与餐前无异。本文示厌食小儿血生长抑素水平显著高于正常儿童。因生长抑素抑制胃肠分泌、运动、血流量,延迟了食物的吸收,因此血生长抑素水平升高可部分解释厌食小儿的消化道功能。其生长抑素升高的原因尚待进一步研究。
In pediatrics it is well recognized that small children may refuse to eat for long period of time without any demonstrable organic disease. The present study investigated somatostatin (SS) and gastrin levels in refusal to eating children (RTE). Peripheral plasma concentrations of somatostatin and gastrin were measured by RIA before and 1 hr after breakfast in 12 RTE children aged 9m-4. 5y (average 2y3m). The basic SS levels in the RTE were 2 times higher than that in the control. The basic gastrin levels in the RTE were no significantly diferent to the control. One hour after feeding SS levels fell from 232. 27?1. 08 to 172. 32?3. 48 ng/L. whereas gastrin levels were reduced or remained the same levels before meal. As SS inhibits gastrointestinal secretion and mobility as well as mesentenc blood flow and delay absorption of food,the RTE could be explained at least in part by the elevated SS. The origin of high concentration of plasma SS in RTE children is unknown.
