摘要
目的观察健肝胶囊对慢性乙型肝炎的疗效。方法68例中度慢性乙型肝炎随机分为两组,治疗组给予中药自拟方健肝胶囊口服,每日三次,每次6～8粒,连服1个月为一疗程,根据病情可连服2～3个疗程;对照组给服大黄蛰虫丸,疗程同前。在服药期间定期查肝功能、γ球蛋白、血清透明质酸、Ⅲ型前胶原肽、Ⅳ型胶原和层粘蛋白。结果治疗组丙氨酸氨基转移酶、天门冬氨酸氨基转移酶和总胆红素下降速度明显快于对照组;自觉症状的改善情况也好于对照组:三个疗程后治疗组各项肝纤维化指标以及γ球蛋白均较治疗前显著下降(P<0.01),而对照组变化不甚明显。结论健肝胶囊对慢性肝炎有良好的抗纤维化和改善肝功能作用。
Objective To observe the therapeutic efficacy of JianGan Capsule on chronic hepatitis B.Methods 68 cases with chronic hepatitis B were randomly divided into two groups, the therapy group received 6-8 pills of JianGan Capsule three times a day for 2-3 months, the control group received 3 g of Dahuang Zhichong pills three times a day. During the course of study, liver function, γ-globulin, serum hyaluronic acid （HA）、procollagen Ⅲ（ PCⅢ）, collagen Ⅳ（ C- Ⅳ） and laminin （LN） were regularly detected by chemical method, electrophoreses and radioimmunoassay, respectively. Results The serum alanine aminotransferase （ ALT ）, aspartate aminotransferase （ AST ）, and total bilirubin （TB） decreased much faster in therapy group than control group. After 3 courses of JianGan treatment, serum HA, PC Ⅲ C-Ⅳ, LN and γ-globulin reduced significantly as compared with basal values（ P〈0.01 ）, while patients received Dahuang Zhichong pills had no significant changes in serum HA,PCⅢ ,C-Ⅳ ,LN and γ-globulin. Conclusion JianGan Capsule has good therapeutic efficacy on chronc hepatitis B in anti-liver fibrosis and improving hver function.
出处
《中国临床保健杂志》
CAS
2005年第4期326-328,共3页
Chinese Journal of Clinical Healthcare
基金
江苏省镇江市科技指导(社会发展)项目(SH01058)
关键词
肝炎
乙型
慢性
肝纤维化
中药疗法
Hepatitis B, Chronic
Liver fibrosis
Pharmacotherapy, TCD
