摘要
目的观察术后三维适形放疗加替莫唑胺同步和辅助化疗治疗恶性脑胶质瘤的近期疗效和不良反应.方法收集2008年1月至2010年6月收治的23例恶性脑胶质瘤切除术后患者,行三维适形放疗2.0 Gy/(次.d),5 d/周,总剂量60～70 Gy,替莫唑胺同步化疗6周+辅助化疗5疗程.结果 23例患者有效率为82.6%,6个月无疾病进展生存率为73.9%(17/23),1 a无疾病进展生存率52.2%(12/23),1 a生存率为69.6%(15/23);患者对治疗的耐受性良好,常见的不良反应为恶心、呕吐.结论恶性脑胶质瘤术后三维适形放疗联合替莫唑胺化疗近期疗效较好,且患者对治疗的耐受性较好,是目前较好的治疗方案.
Objective To observe the clinical efficacy and side effects of three-dimensional conformal radiotherapy concomitant with temozolomide in the treatment of postoperative malignant gliomas in Chinese patients.Methods Twenty-three malignant glioma patients previously treated with resection of the tumor received three-dimensional conformal radiotherapy with concomitant and adjuvant temozolomide chemothreapy.Results The overall response rate was 82.6%.The progression-free survival was 73.9%(17/23)at 6 months and 52.2%(12/23)at 1 year respectively.The one-year survival rate was 69.6%(15/23).All patients could well tolerate this treatment scheme.The main side effects were nausea and vomit.Conclusions Three dimensional conformal radiotherapy concomitant with temozolomide in the treatment of postoperative malignant gliomas demonstrates good tolerance and short-term efficacy.
出处
《昆明医学院学报》
2011年第12期97-100,共4页
Journal of Kunming Medical College
基金
云南省科技厅社会发展科技计划基金资助项目(2010ZC129)
关键词
三维适形放疗
替莫唑胺
恶性胶质瘤
Three-dimensional conformal radiotherapy
Temozolomide
Malignant gliomas
