摘要
目的探讨慢性阻塞性肺疾病患者气道局部氧化应激水平以及盐酸氨溴索对其影响。方法将80例急性加重期慢性阻塞性肺疾病患者,随机分为对照组和治疗组。对照组给予常规治疗,治疗组在常规治疗的基础上再给予盐酸氨溴索30 mg/d,静脉点滴。治疗前后留取诱导痰,检测诱导痰中MDA、SOD水平。结果 (1)与空白对照组相比,对照组和治疗组患者诱导痰中MDA水平明显增高,SOD水平明显降低,差异有统计学意义(P<0.05),对照组和治疗组之间差异无统计学意义(P>0.05)。(2)与治疗前相比,对照组和治疗组患者诱导痰MDA水平明显下降,SOD水平明显增高,差异均具有统计学意义(P<0.05)。与对照组相比,治疗组患者诱导痰中MDA明显降低,SOD水平明显增加(P<0.05)。结论慢性阻塞性肺疾病患者急性发作期肺脏局部氧化应激水平增高,盐酸氨溴索可有效降低肺脏局部氧化应激水平,可作为一种有效的辅助治疗方式应用于临床。
Objective To explore the oxidative stress levels in airway from patients with chronic obstructive pulmonary disease(COPD) and the effects of ambroxol on the oxidative stress.Methods 80 patients with acute COPD in our hospital from January 2008 to December 2009 chest ward were selected and randomly divided into control group and treatment group.Patients in control received conventional therapies and the patients in treatment group were given ambroxol 30 mg/d,intravenously,besides the conventional therapies.Induced sputum was obtained before and after treatment for the detection of MDA and SOD.Results(1) Compared with that in blank control,an increased MDA and decreased SOD levels were found in patients from control group and treatment group,with P<0.05.The difference between the control group and treatment group did not hold the significance,with P>0.05.(2) Compared with that before treatment,a decreased MDA and increased SOD levels in induced sputum patients form the control and treatment group were obtained,with P<0.05.Compared with that in control after the treatments,a decreased MDA and increased SOD levels in induced sputum patients form treatment group were obtained,with P<0.05.Conclusion There was abnormal oxidative stress in lung in patients with acute COPD;ambroxol could reduce oxidative stress in the lung and can be used as a useful adjuvant therapy for COPD patients.
出处
《湖南中医药大学学报》
CAS
2011年第10期45-46,49,共3页
Journal of Hunan University of Chinese Medicine
关键词
慢性阻塞性肺疾病
氧化应激
诱导痰
氨溴索
Chronic obstructive pulmonary disease
Oxidative stress
Induced sputum
Ambroxol
