期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

NMDA依赖的突触长时程增强和长时程抑制模型与仿真研究

A model and simulation research of NMDA-depended bidirectional synaptic plasticity
在线阅读 下载PDF
导出
摘要 目的:探究突触长时程增强和长时程抑制与NM-DA受体亚型活性状态间的相关机制.方法:通过对NMDA受体亚型通道的动力学差异特性进行分析,提出一个修正的突触后钙信号模型来描述NMDA受体不同亚型的活性状态与突触前刺激频率的关系,并结合突触后钙依赖信号网络模型,建立了一个关于海马CA3-CA1突触长时程增强和长时程抑制的生物物理模型.结果:根据LTP和LTD诱导条件,对NMDA依赖的突触长时程增强和长时程抑制的诱导和形成过程进行了仿真.结论:诱导LTD所需的钙暂态可能来源于NMDA通道的NR2B亚型的钙内流,而与LTP的诱导过程相对应的钙信号可能主要是通过该受体NR2A亚型通道的钙内流产生. AIM ： To study the correlative mechanism between the induction of long term modification and the activity of different NMDA receptor subtypes. METHODS： Based on the analysis of dynamic properties of NMDA receptor subtypes, an amended mathematical model of postsynaptic calcium was proposed to describe the relationship between different NMDA receptor subtype activity and presynaptic stimulus frequency. Along with a biochemical-reaction networks model of the postsynaptic Ca^2＋-depended signaling pathways, we developed a unified biophysical model about the hippocampal CA3-CAI synapses bidirectional plasticity. RESULTS： According to the inductive condition of long-term potentiation （LTP） and long term depression （LTD）, our computer simulation mimicked the induction processes of NMDAR-dependent long term modification. CONCLUSION： It is elucidated that the calcium transients required for LTD may primarily come from the calcium inflow mediated by NR2B subtype channel of NMDA receptor and the induction of LTP may require the calcium inflow mediated by NR2B subtype channel.
作者 董爱荣 谭小丹 苏永春 高天明 邓亲恺
机构地区 南方医科大学医学物理教研室 南方医科大学生理教研室
出处 《第四军医大学学报》 北大核心 2005年第16期1529-1532,共4页 Journal of the Fourth Military Medical University
基金 国家自然科学基金(30125013 303300240)
关键词 长时程增强 长时程抑制 受体 N-甲基-D-天冬氨酸 生物物理模型 long-term potentiation long-term depression receptors, N-methyI-D-Aspartate biophysicalmodel
分类号 Q42 [生物学—神经生物学] Q811 [生物学—生物工程]
  • 相关文献

参考文献8

  • 1Sheng M, Kim MJ. Postsynaptic signaling and plasticity mechanisms[ J ], Science, 2002 ;298: 776 - 780.
  • 2Liu LD, Wong TP, Pozza MF, et al. Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity[J]. Science, 2004;304:1021 - 1024.
  • 3Castellani GC, Qinlan EM, Cooper LN, et al. A biophysical model of bidirectional synaptic plasticity: Dependence on AMPA and NMDA receptors [J]. PNAS, 2001 ;98: 12772 - 12777.
  • 4Shouval HZ, Bear MF, Cooper LN. A unified model of NMDA receptor-dependent bidirectional synaptic plasticity [ J ]. PNAS,2002 ;99 ( 16 ): 10831 - 10836.
  • 5Zhabotinskyd AM. Bistability in the Ca2 +/Calmodulin-dependent protein kinase-phosphatase system [ J ]. Biophys J, 2000; 79 ( 5 ):2211 - 2221.
  • 6Mulkey RM, Endo S, Shenolikar S, et al. Involvement of a calcineurin/inhibitor-1 phosphatase cascade in hippocampal long-term depression [J]. Nature, 1994 ;369:486 -488.
  • 7蒋马莉,韩太真,杨东伟.GluR1在大鼠海马结构的表达[J].第四军医大学学报,2003,24(20):1849-1850. 被引量：1
  • 8Bayer KU, Koninck PD, Leonard AS, et al. Interaction with the NMDA receptor locks CaMKII in an active conformation [ J ]. Nature, 2001 ;411: 801 -805.

二级参考文献8

  • 1[1]Song I, Huganir RL. Regulation of AMPA receptors during synaptic plasticity [review] [J]. Trends Neurosci, 2002; 25(11):578-588.
  • 2[2]Lee HK, Takamiya K, Han JS, Man H, Kim CH, Rumbaugh G, Yu S, Ding L, He C, Petralia RS, Wenthold RJ, Gallagher M, Huganir RL. Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory [J]. Cell, 2003; 112(5): 631-643.
  • 3[3]Reisel D, Bannerman DM, Schmitt WB, Deacon RM, Flint J, Borchardt T, Seeburg PH, Rawlins JN. Spatial memory dissociations in mice lacking GluR1 [J]. Nat Neurosci, 2002; 5(9):868-873.
  • 4[4]Shi SH, Hayashi Y, Esteban JA, Malinow R. Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons [J]. Cell, 2001;105(3):331-343.
  • 5[5]Nusser Z. AMPA and NMDA receptors: Similarities and differences in their synaptic distribution [review] [J]. Curr Opin Neurobiol, 2000; 10:337-341.
  • 6[6]Barry MF, Ziff EB. Receptor trafficking and the plasticity of excitatory synapses [review] [J]. Currt Opin Neurobiol, 2002; 12:279-286.
  • 7[7]Kanterewicz BI, Urban NN, McMahon DB, Norman ED, Giffen LJ, Favata MF, Scherle PA, Trzskos JM, Barrionuevo G, Klann E. The extracellular signal-regulated kinase cascade is required for NMDA receptor-independent LTP in area CA1 but not area CA3 of the hippocampus [J]. J Neurosci, 2000; 20(9):3057-3066.
  • 8[8]Arai A, Lynch G. Response to repetitive stimulation of AMPA receptors in patches excised from fields CA1 and CA3 of the hippocampus [J]. Brain Res, 1996; 716:202-206.
第四军医大学学报
2005年 第16期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部