摘要
目的观察原发性血小板减少性紫癜患儿幽门螺杆菌(HP)感染对免疫球蛋白及补体的影响。方法对267例原发性血小板减少性紫癜患儿进行13C尿素呼吸试验检测,将HP阳性的患儿选入研究组(n=60),同时随机选择HP阴性的患儿作为对照组(n=58),观察所有研究对象的免疫球蛋白(IgM、IgA和IgG)和补体(C3和C4)情况。结果两组患儿的IgM、IgA、IgG和C3、C4的检测结果差异均有统计学意义,其中研究组明显高于对照组(P<0.05)。结论 HP感染明显影响原发性血小板减少性紫癜患儿的免疫球蛋白和补体,可作为根治HP的临床疗效观察指标。
Objective To investigate the effects of helicobacter pylori (HP) infection on immunoglobulins and complements in children with thrombocytopenic purpura (TP) .Methods A total of 267 children with TP were detected by 13C-urea breath test.The children who had HP positive result were selected into trial group (n=60) ,and those with HP negative result were selected into control group (n=58) .The levels of immunoglobulins (IgG,IgA,IgM) and complements (C3,C4) were measured.Results There were statistical differences in the levels of IgG,IgA,IgM,C3 and C4 between the two groups,i.e.the levels of the above parameters were higher in the trial group than in the control group (P<0.05) .Conclusion HP infection significantly affects immu-noglobulins and complements in the childrn with TP,which may act as the indexes reflecting the clinical effects of HP radical treatment.
出处
《临床军医杂志》
CAS
2010年第4期597-598,共2页
Clinical Journal of Medical Officers
