摘要
目的研究健康人群、肥胖和2型糖尿病(T2DM)患者的血清脂联素/瘦素(APN/LEP)与胰岛素抵抗指数的关系。方法采用病例对照研究,2型糖尿病伴有肥胖组(DO)42例,T2DM不伴肥胖组(NDO)42例,单纯性肥胖组(OB)37例,正常对照组(NC)28名。检洲了4组研究对象血脂、血糖(FBG)、空腹胰岛素(Fins)、APN、LEP水平,用HOMA模型公式计算胰岛素抵抗指数(HOMA-IR)。结果正常对照组(NC)的脂联素/瘦素明显大于其它三组,统计学检验差异有显著性意义(P<0.05),而其它三组间的脂联素/瘦素差异无显著性意义。糖尿病肥胖组(DO)的HOMA-IP<明显高于其它三组,统计学检验差异有显著性意义(P<0.05)。随着脂联素/瘦素的降低,胰岛素抵抗指数呈上升趋势。结论胰岛素抵抗指数与脂联素/瘦素间呈显著负相关,脂联素/瘦素有望成为反映胰岛素抵抗的新指标。
Objective To investigate the relationship between APN/LEP and insulin resistance index among healthy people,obese people and type 2 diabetes mellitus patients.Methods A case-control study was used in the research.42 cases with type 2 diabetes and obesity(DO),42 cases with type 2 diabetes and not obesity(NDO),39 cases with type obese subjects(OB)and 28 healthy people used for normal control group (NC)were selected for the research.Serum lipids,fasting glucose,fasting insulin,adiponectin and leptin were measured in the four group subjects.According to the typical HOMA model,insulin resistance index was calculated. Results The result showed that APN/LEP was significantly higher in group NC than that of the other three groups(P<0.05),and there was no significant difference among the three groups.HOMA-IR was significantly higher in group DO than that of the other three groups(P<0.05).The insulin resistance index takes on a rise with the decrease on the ratio of adiponectin and leptin.Conclusion HOMA-IR negatively correlated with APN/LEP,and APN/LEP may be become a new index to reflect insulin resistance.
出处
《热带病与寄生虫学》
2010年第2期86-87,90,共3页
Journal of Tropical Diseases and Parasitology
关键词
脂联素/瘦素
胰岛素抵抗
2型糖尿病
Adi po necdn/Lept i n
I nsul i n r esi s t ance
Type 2 di abetes mel l i tus
