摘要
在大鼠20%体表面积Ⅲ变烫伤的动物模型上,观测了伤后不同时间内的Mφ和淋巴细胞功能的变化。巨噬细胞吞噬功能没有变化,IL-1产生升高(伤后1—3天),淋巴细胞转化降低(3天)J,IL-2产生明显降低(12小时—5天)。这一变化与伤后机体应激状态时体内代谢和免疫功能的变化密切相关。
The function oflymphocytes and macrophages aftera 20% full-thickness scald injures in a rat model was observed. A.fter injures, no significant change was found inphagocytic activity of macrophage. The interleukin 1 (IL-1) activity increased on 1th, 3th, 5th day (P<0.05) as compared with control. This result showed that the function of phagocytosis in macrophage is different from secretion. Lymphocyte proliferation decreased in ConA stimulated on 3th day after injury, the interleukin 2 (IL-2)activity decreas edsignificantly on all days (12hr—5th day)(P<0.01).Tkese might be related to the decrease of IL-2 and the decrease of immune function after burn injury.
