摘要
冠心病（ＣＨＤ）危险的增加与性激素的不足密切相关。我们测定了６６０名健康妇女（１４～７５岁）绝经期前、后血脂和脂蛋白的浓度。观察到总胆固醇（ＴＣ）、甘油三酯（ＴＧ）、低密度脂蛋白胆固醇（ＬＤＬ—Ｃ）、极低密度脂蛋白胆固醇（ＶＬＤＬ—Ｃ）、ＴＣ／ＨＤＬ—Ｃ和ＬＤＬ—Ｃ／ＨＤＬ—Ｃ的比率随年龄增大而明显增高。绝经后妇女的ＴＧ、ＴＣ、ＬＤＬ—Ｃ、ＶＬＤＬ—Ｃ、ＴＣ／ＨＤＬ—Ｃ和ＬＤＬ—Ｃ／ＨＤＬ—Ｃ比率明显高于绝经前的妇女（Ｐ＜０．００１或０．００５），而高密度脂蛋白胆固醇（ＨＤＬ—Ｃ）无明显变化。这些变化可以部分解释绝经妇女ＣＨＤ发病率增高的现象。
Sex hormone deficiency is associated with the increasing risk of coronary heart disease in women. We measured serum lipids and lipoprotein concentrations in a group of 660 premenopansal and postmenopausal women (14-75 year-old). With the increase of age,the concentrations of total cholesterol(TC), very low density lipoprotein (VLDL)cholesterol, TC/HDL -C (high density lipoprotein cholesterol) and LDL - C/HDL-C also increased. The postmenopausal women had significantly higher concentration of TG, LDL-C, TC, VLDL -C, TC/HDL-C and LDL/HDL-C than premenopausal women (P<0. 001 or 0. 005)while HDL-C kept stable. These changes might partly explain the increased incidence of coronary heart disease in postmenopausal women.
出处
《中国冶金工业医学杂志》
1995年第1期10-11,共2页
Chinese Medical Journal of Metallurgical industry
