摘要
目的:研究生长抑素(SS)和GABA对大鼠海马长时程增强(LTP)的影响.方法:采用穿梭箱主动回避反应(AAR)法和以海马CA1区群体峰电位(PS)为LTP的指标. 结果:AAR习得达标鼠,PS增幅达100％以上;海马内注射(ih)SS(1 g L^(-1))后,PS增幅大于120％;ih SS耗竭剂半胱胺(Cys,20gL^9-1))后,PS不出现(n=8)或PS增幅不及10％(n=3);ih GABA(200g L^(-1))后,PS增幅小于30％,且有拮抗SS增强LTP的效应. 结论:SS有易化LTP的作用,而GABA则有相反的效应,二者共同参与调控海马突触传递的信息,从而影响学习和记忆.
To study the effect of somatostatin (SS) and GABA on the long-term potentiation (LTP) of hippocampal CAl area in rats. METHODS: Active avoidance response (AAR) of shuttle-box was recorded and population spikes(PS) were taken as indices of LTP. RESULTS: Increased percentages of PSA (PS amplitude, in AAR-acquired rats are more than 100 % ; After intrahippocampal injection (ih) of SS (1g L-1), increased percentages of PSA exhibited above 120 %. Increased percentages of PSA were significantly decreased (<10 % , n = 3) and even caused no PS (n = 8) by ih cysteamine (Cys, 20 g L-1, the depletor of SS); ih GABA (200 g L-1) indicated that the increased percentages of PSA are less than 30 % , GABA weakened the effect of SS on LTP. CONCLUSION : SS enhance hippocampal LTP but GABA decrease it; they may influence each other to regulate the hippocampal synaptic transmission in the process of learning and memory.
出处
《中国药理学报》
CSCD
1995年第4期380-382,共3页
Acta Pharmacologica Sinica
基金
Project supported by the National Natural Science Foundation of China
№39170295.
关键词
海马
生长抑素
半胱胺
GAGA
回避性学习
记忆
hippocampus
microinjections
somatostatin
cysteamine
GABA
avoidance learning
memory
