摘要
基于水杨酸在ｐＨ２的盐酸介质中与Ｆｅ３＋生成紫色络合物，在５２０ｎｍ处有强吸收，而乙酰水杨酸无干扰的原理，建立了流动注射光度法测定原料药乙酰水杨酸中杂质水杨酸的含量，方法快速、简便。在０．０１～０．２０ｍｇ／ｍｌ浓度范围内线性关系良好，方法回收率为１０１．５％。
Salicylic acid reacts with Fe3+in pH 2 hydrochloric acid medium to form a violet complex,showing a strong atherption at 520 nm. A flow injection spectrophotometry for the determination of satlicylic acid in bulk pharmaceutical of acetyl salicylic acid is described based on the above reaction.The method is sensitive and accurate the linear range is from 0.01 to 0.20 mg/ml,and the recovery is 101.5%.Meanwhile,it has a high sampling rate of 90 samples per hour.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
1995年第5期273-275,共3页
Journal of China Pharmaceutical University
关键词
乙酰水杨酸
水杨酸
流动注射光度法
Salicylic acid
Acetyl salicylic acid
Flow injection spectrophotometry
