摘要
河南省某大型鸽场发生以神经症状、拉绿色或白色稀便、出血性肠炎和肝肿大出血为特征的传染病,共死鸽3000羽,经病原分离鉴定和动物接种试验及随后检查多批由该场和郊县送检的病、死鸽及血清,证明引起鸽死亡的主要传染病是鸽巴氏杆菌病和沙门氏菌病。用从病、死鸽分离的多杀巴氏杆菌和鼠伤寒沙门氏菌制成二联灭活苗(下称二联苗),用副粘病毒制成副粘病毒油乳剂灭活苗。将二联苗和副粘病毒油乳剂灭活苗同时接种鸽,其沙门氏菌抗体80％阳性,巴氏杆菌抗体70％阳性;副粘病毒HI几何平均值为6log_2。用巴氏杆菌和鼠伤寒沙门氏菌攻毒100％保护,而未免疫组攻毒100％死亡。用以上二种疫苗免疫鸽60余万羽份,经2年多的流行病学调查和抽样检验表明,研制的疫苗安全,有坚强和持久的免疫力。
3000 pigeons died as infectious diseases broke in a big pigeon farm in Henan. Clinical signs are characterized as nerve symptoms, green or white diarrhea, haemorrhagic enteritis and the lessions in livers. It was diagnosed that the pigeons died of Pasteurella Multocida (P. multocida) and Salmonella Typhimurium (S. typhimurium) infection by means of pathogenic isolation and animal inoculation. A combined vaccine against P. multocida and S. typhimurium was developed using the isolated P. multocida and S. typhimurium. An oil-emulsion vaccine a-gainst pa'vamgxovirus was developed and inoculated with the combined vaccine at same time. 80% of the samples were positive to salmoriella70%were positive to Pasteurella in antibody tests. No clinical signs or mortality was present when the immunized pigeons were attacked with virulent P. multocide and S. typhimurium. The HI antibody geomebrie meantibre to paramyxovirus was 6log2. More than 600000 pigeons had been inoculated with the above vaccines, after more than two years epidemiological investigation and sample tests. It was concluded that the vaccines were safe and the pigeons got stable and druable immunological effects after inoulatidn.
