摘要
在体外研究了地塞米松（Ｄｅｘ）对豚鼠离体气管平滑肌收缩的影响。ＣａＣｌ２和组胺（Ｈｉｓ）引起了气管条明显的收缩，ｐＤ２分别为３．９及５．９２。用地塞米松温育后，氯化钙和组胺的量效曲线均明显降低，ｐＤ＇２分别为４．７４和６．６７。Ｄｅｘ对Ａｃｈ３×１０－６ｍｍｏｌ·Ｌ－１和前列腺素Ｆ２α３ｍｍｏｌ·Ｌ－１引起的支气管平滑肌收缩也有逆转作用，ＩＣ５０分别为２．４１×１０－５ｍｏｌ·Ｌ－１和４．２６×１０－４ｍｏｌ·Ｌ－１，提示Ｄｅｘ有明显的支气管扩张作用。
The effect of Dex on isolated tion was studied in vitro.CaCl2 and histamine caused significant tracheal smooth muscle contraction and PD was 3.9 and 5.92 respectively.After incubated with Dex, the doseresponse curve of CaCl2 and His was significantly depressed was PD’and 4. 74 and 6. 67. Dex could also inhibited isoguinea-pig tracheal smooth muscle contraclated tracheal strips contraction induced by Ach 3×10-6 mol·L-1 and PGF2a 3 mmol·L-1. IC50 were 2.4×10-5 mol· L-1 and 4.26×10-4 mol· l-1. Dex had significant dilated effect on tracheal smooth muscle.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1995年第5期403-406,共4页
Chinese Pharmacological Bulletin
