摘要
采用间隔２４ｈ两次静脉注射内毒素方法制作家兔内毒素性播散性血管内凝血（ＤＩＣ）模型，同时给予生理盐水、地塞米松和热毒清等不同处理。结果：地塞米松组和热毒清组造模后测得的血浆肿瘤坏死因子（ＴＮＦ）、全血血小板活化因子（ＰＡＦ）、外周血单个核细胞（ＰＢＬＭＮＣ）诱生ＴＮＦ和诱生白细胞介务－１（ＩＬ－１）的水平均较模型组有明显降低（Ｐ＜０．００１～０．０５）；病理学检查亦发现地塞米松组和热毒清组家兔的肝、肺组织出血、坏死和肝、肺、肾组织中微血栓形成的程度均较模型组轻。说明热毒清和地塞米松均能阻抑内毒素性ＤＩＣ的发生和发展，其作用机制可能是降低血液中ＴＮＦ、ＩＬ－１和ＰＡＦ等炎症介质的水平，从而减轻血管内皮细胞和组织器官损伤，防止凝血系统激活。
In this study,disseminated intravascular coagulation(DIC ) model of rabbits was made by injectionglipopolysacchride(LPS)twice at 24 hours interval. Wefound the levels of plasma tumor necrosis factor (TNF)platelet activating factor (PAF) and Peripheral bloodmonocyte induced imterleukin-1(IL-1),TNF in salinegroup were significantly higher than dexamethone(DXM)group and re du qing(RDQ)group(P<0.001～0.05 ).Histologically it was found that the livers andlungs of saline group were damaged more seriously thanthose of DXM and RDQ groups.The fibrin thrombi inthe livers, lungs and kidneys of saline group were milderthan those of the other two groups. These results suggestthat RDQ and DXM can inhibit the emergence and evo-lution of DIC. The possible mechanism is that the de-creased levels of blood TNF,IL-1 and PAF are inducedby RDQ and DXM so that the damages of vascular en-dothelial cells, tissues and organs are alleviated and theactivation of the coagulation system is prevented.
出处
《中国危重病急救医学》
CSCD
1995年第4期193-195,共3页
Chinese Critical Care Medicine
关键词
热毒清
中药
播散性
血管内凝血
肿瘤坏死因子
re du qin
endotoxic disseminated intravas-cular coagulation
tumor necrosis factor
interleukin-1
platelet-activating factor
