摘要
在肝微粒体水平上，采用依诺沙里４００ｍｇ／ｋｇ，灌胃ｑｄ×７ｄ能显著减少大鼠肝微粒体细胞色素Ｐ４５０。含量，经依诺沙星处理的大鼠肝微粒体中氨基比林－Ｎ－脱甲基酶、ＮＡＤＰＨ－细胞色素Ｃ还原酶、７－乙氧基香豆素－Ｏ－脱乙基酶、苯并芘羟化酶、戊巴比妥侧链羟化酶的活性均显著减弱。可见，依诺沙星对大鼠肝药酶具有广泛的抑制作用。
Enoxacin has bcen developed as an effective‘antibacterial agent and was widely used to treat a varicty of infections. It was reported that enoxacin markeclly inhibitedthe activity of cytochrome p-450 in livcr microsomes,In this report,the effects of enoxacinon many hepatic drug-metabolizing enzymes were investigated.Oral administration of enoxacin 400 mg/kg once daily for 7 days significantly inhibitedliver michrosomal cytochrome p-450,NADPH-cytochrome C reductase,aminopyrine-N-demethylase,7-ethoxycoumarin-O-deethylase,benzo(a)pyrine hydroxylase and pentobarbitalside Chain hydroxvlase activities in rats.The above results strongly suggest that enoxacin is an inhibitor of drug-metabolizingenzymes in rat liver,and this agent should be used with care with aminophylline,caffein andwarfarine that are also metabolized in the liver by drug-metablizing enzymes.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
1995年第5期384-388,共5页
Chinese Journal of Antibiotics
基金
四川省教委
重庆市科委博士基金
关键词
依诺沙星
肝微粒体
肝药酶
酶抑制剂
Enoxacin
Liver microsomes
Drug-metabolizing enzyme
Enzymeinbibitor
