摘要
用Langendorff法与微电极技术研究刺五加对大鼠离体心脏缺血再灌心律失常与细胞动作电位的作用。刺五加浸膏(1.2～2.4mg生药/ml)使室颤和室速发生率明显下降,使正常窦律时间增加,并可使异常动作电位显著减少。
By means of Langendorff method and standard microelectrode techniques the effects of Ciwujia on roperfusion induced arrhythmias and action potential alterations were studied in isolated rat heart with transient coronary occlusion. Inclusion of Ciwujia extract (equivalent to 1.2 and 2.4 mg crude drug/ml) was found helpful in reducing reperfusion induced ventrieular fibrillation and ventricular tachycardid. Associated with this reduction in rhythm disturbances was an increase in the total duration of normal sinus rhythm during the 3 min reperfusion period. With the administration of Ciwujia the number of cells with abnormal action potential configurations was significantly reduced. This confirms that Ciwujia can protect myocardium from electrophysiological abnormalities, and therefore reduces the incidence of malignant arrhythmias.
出处
《中国中药杂志》
CAS
CSCD
北大核心
1989年第8期45-47,60,共4页
China Journal of Chinese Materia Medica
关键词
刺五加
心律失常
动作电位
大鼠
Ciwujia (Acanthopanax senticosus)
ischemia-reperfusion
action potential
