摘要
本文应用刺激家兔腓总神经、体表记录脊髓诱发电位(SEP)的方法,研究了溴氰菊酯不同剂量iv对SEP的影响,并与脊髓兴奋剂士的宁及脊髓运动神经元抑制剂美索巴莫的作用进行了比较。结果表明,溴氰菊酯2 mg/kg iv可以使SEP的N_3之后的波形和波幅发生变化。这种作用与士的宁的作用有某些相似。美索巴莫能部分拮抗溴氰菊酯的作用。
Spinal evoked potential (SEP)was recorded from the spinal cord surface by stimulating the perpneal nerve of rabbit The effect on SEP following intravenous injection of deltamethrin was observed.The actions of spinal neuron exciting agent strychnine and spinal motor neuron inhibiting agent methocarbamol were compared with the effect of deltamethrin.The results showed that the shape and amplitude of waves behindN2 in SEP were changed after the administration of 2mg/kg cf deltamethrin iv.Such an effect was similar to that of strychnine.Methocarbamol can partially antagonize the effect produced by deltamethrin.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
1989年第1期57-62,共6页
Chinese Journal of Pharmacology and Toxicology
关键词
溴氰菊酯
脊髓
诱发电位
家兔
deltamethrin
strychnine
methccartamol
cpinal cord
spinal evoked potentials
