摘要
目的 研究蛇毒神经生长因子 ( s N GF)对大鼠坐骨神经损伤后诱发电位的影响 ,评价蛇毒神经生长因子在促进周围神经再生中的作用。 方法 建立大鼠坐骨神经钳夹模型 ,局部滴加药物和术后肌注s NGF,通过脊髓诱发电位 ( SEP)、运动诱发电位 ( MEP)评定 ,观察坐骨神经修复情况。 结果 s NGF治疗可使伤后 SEP、 MEP提早出现。 结论 蛇毒提取的
Objective To investigate the effects of snake nerve growth factor(sNGF)on repairing crushed injury sciatic nerves in rats Methods The animal models of the crushed sciatic nerve were established in 30 wistar rats ,which divided into 3 groups:normal saline(NS) group, snake nerve growth factor(sNGF) group and normal control group the sNGF was dropped into local sites and injected intramuscularly once a day for 14 days after operation Functional repair for the crushed sciatic nerves was studied by the examination of somatosensory evoked potential(SEP)?motor evoked potential(MEP)?distance between first and fifth toes (TS)and observation of autotomy Results At 2 weeks after crushing, the SEP was elicited in 86% of sNGF group,and in 26%of NS group(P<0 01),the SEP's lantenscy of NS group was longer than sNGF group at 4 week The MEP was elicited in 76% of sNGF group and none of the control group(P<0 01) at 2 weeks The TS was longer than control group at 2?3 weeks Conclusion NGF can significantly promote the functional repair of injuried peripheral nerve
出处
《蛇志》
2002年第3期9-11,共3页
Journal of Snake
关键词
蛇毒
神经生长因子
周围神经再生
诱发电位
Nerve growth factor(NGF)
Crushed nerve injury
Nerve regeneration
