摘要
用木糖醇治疗121例非胰岛素依赖型糖尿病(NIDDM)患者,结果表明有较好的降血、尿糖及糖化血清蛋白的效果。降血糖显效率为54.5％(66/121),有效率达84.3％(102/121),显效率高于D860对照组,有效率两组间无显著差异。并发现木糖醇具有较好的护肝降血清转氯酶作用。日剂量37.2g,连服21天,未发现明显毒副作用,仅见10％左右患者于服药第1周内出现胃肠道反应,主要表现为渗透性腹泻、上腹不适、便次增多、恶心等,继续服用都适应性自愈。结果提示,木糖醇可作为NIDDM的一种辅助降糖药,特别适合于轻、中型及合并有轻度肝功异常和便秘或伴肥胖的NIDDM患者,对于重型NIDDM患者可与其它降糖药物联合应用。
Xylitol was used to treat 121 patients with non-insulin-dependent diabetes mpllitus (NIDDM). The daily oral dose of xylitol was 37. 2g/day. After a 21-day course of treatment, levols of blood glucose,urine glucose,and glycated serumprolein protein were all greatly decreased (P< 0. 01) in the patients. The efficacy rate of reducing blood glucose was 84. 3% (102/121) ,which was similar to that of D860. Side effects of xylitol was mild and mainly appeared as disorder of entero-gastric tract. When first week of treatment ended, about 10% of patients complained of such symptoms. After another week's treatment, these symptoms disappeared spontaneously. In addi-tion,xylitol has effects on protecting liver function and decreasing serum transaminase. The survey indicated that xylitol could act as a supplementary hypoglycemic agent in NIDDM.
出处
《天津医药》
CAS
1995年第8期476-479,共4页
Tianjin Medical Journal
关键词
非胰岛素依赖型
糖尿病
木糖醇
药物疗法
xylitol non-insulin-dependent diabetes mellitus (NIDDM ) tolbutamide (D860)
