摘要
应用放射免疫方法和彩色多普勒超声心动图对59例不稳定性心绞痛(UAP)患者和34例正常人分别测定血浆心钠素(ANP)、肾素(PRA)、血管紧张素Ⅱ(A_Ⅱ)、醛固酮(Ald)水平及各房、室腔内径。结果显示UAP患者血浆ANP、PRA、An含量均明显增高(P<0.005).Ald含量无明显变化(P>0.05),且ANP含量与心房内径呈正相关,表明UAP患者肾素-血管紧张素-醛固酮系统(RAAS)活性增强,在UAP的形成和发展中起重要作用,ANP浓度增加对其损害起缓解作用。
The determinations of atrial natriuretic peptide (ANP) ,renin(PRA) ,angiotensin II(AII),al-dosterone(Ald) in plasma using radioimmunological method and atria! and ventricular diameters using ultrasound were performed for 59 patients with unstable angina pectoris(UAP) and 34 nor-mal persons. The results showed that ANP.PRA and AH in plasma increased(P<0. 05),and Ald did not change in patients with UAP(P>0. 05). The concentration of ANP was positively correlat-ed with atrial diameter(P<0. 05). It is suggested that the activity of renin-angiotensin-aldosterone system(RAAS) in patients with UAP was stronger than in controls. RAAS playcd an important role in the formation and development of UAP. However, increased ANP could diminish the cardiac damage.
出处
《天津医药》
CAS
1995年第8期473-475,共3页
Tianjin Medical Journal
关键词
不稳定性
心绞痛
血浆
心钠素
肾素
血管紧张素
unstable angina pectoris atrial natriuretic peptide renin angiotensin aldosterone
