摘要
本文观察了不同剂量的莲心碱对正常大鼠血压和心电学的影响。结果表明２～１２ｍｇ／ｋｇ莲心碱静脉注射可产生不同程度的降压作用，其降压效应和有效作用时间呈剂量依赖性。莲心碱降低舒张压的作用大于收缩压，提示该药的主要作用部位在外周血管。此外，莲心碱还可延长ＰＲ、ＱＲＳ和ＱＴｃ间期，提示该药对房室结和心室肌的传导有抑制作用，并可延缓心室复极过程，表明莲心碱具有Ｉａ类抗心律失常药物的电生理特征。大剂量（１２ｍｇ／ｋｇ）给药可引起窦房结自律性的降低，并有诱发严重性心律失常的危险。
Effects of Liensinine in five doses on blood Pressure(BP)and electrocardiology were observed in normal rats. The results showed that intravenous Liensinine in the doses of 2-12mg/kg had different effects in reducing BP and had more effects in decreasing diastolic BP than systolic BP.It was also showed that Liensinine prolonged PR,QRS and QTc intervals, indicating that the drug may inhibit the conduction of atrial ventricular node and intraventricle as well as mav slow ventricular repolarization.12mg/kg of Liensinine reduce the automaticity of sinus node and can induce vital arrhythmiats.
出处
《天津医科大学学报》
1995年第1期23-26,共4页
Journal of Tianjin Medical University
关键词
莲心碱
血压
药理学
Liensinine
Blood Pressure
Electrocardiology
Arrhythmia
