摘要
本文用OKT系列单克隆抗体以流式细胞仪对60例遗传过敏性皮炎(AD)患者(PAD14例、ADR15例、ADI12例及ADRI19例)外周血淋巴细胞亚群进行了检测。结果表明,总患者组T_3^+、T_8^+细胞百分比较正常人显著降低,T_4^+/T_8^+比值升高。在AD分型观察中,ADR、ADI及ADRI等型患者T_8^+细胞显著降低,T_4^+/T_8^+比值升高。AD患者血清IgE显著高于正常人,但与T_8^+细胞低下无相关性。提示T_8~细胞的低下与遗传过敏性背景有关。
The peripheral blood lymphocyte subsets were determined by using monoclonal antibody and flow cytometer in 60 patients withatopic dermatitis (AD). The results showed that the percentage of T3^+ cell and T8^+ cell i n all patients with AD were significantly lower than that of normal control and the overall ratio of T4^+ /T8^+ cells was significantly elevated in AD patients. It wasalso found that the percentage of T4^+/T8^+ cel 1 s was si gnificant1y elevated in AD patients. It was also found that the percentage of T8^+ cell in AD patients with respiratory allergy and ichthyosis was significantly reduced. The results indicated that the reduction of T8^+ cell might contributed to the atopic status of the AD patients.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1989年第5期296-297,317,共3页
Chinese Journal of Immunology
关键词
过敏性皮炎
淋巴细胞亚群
IGE
Atopic Dermatitis: Lymphocyte Subset: T8^+Cell T4^+/T8^+Ratio
