摘要
研究人胚胎横纹肌条件培养液产生的生物因子（ＡＴＦ－ＦＭＣＭ）抗肿瘤活性。观察发现ＡＴＦ对８种肿瘤细胞株体外增殖有抑制作用。对ＢＧＣ－８２３等６种瘤细胞的抑制率均在５２％～９４％之间。其中对ＢＧＣ－８２３、Ｖ－７２２１和Ｈｅｌａ３株瘤细胞的抑制率最高，分别为９４％，９３％和８５％。整体抑瘤实验证实，ＡＴＦ能明显减轻Ｓ－１８０荷瘤小鼠腹水的严重程度，生存时间延长，并能有效抑制ＬＡ－７９５肺腺瘤荷瘤小鼠的肺转移。文中还分析了ＡＴＦ的生化特性和抑瘤机理。
Antitumor activity of biological factor(ATF) in conditioned medium prepared from fetal striated muscle had been studied.The suppresion of tumor cell proliferation of 8 specis with ATF in vitro was demonstrated.The rate of suppresion was 52%～94% in BGC·823 and tumor cell of other 5 specis.The suppresion ratebeing highest in BGC-823,V-7221 and Hela tumor cells was 94%,93% and 85% respectively.ATF reduced the amount of ascites and prolonged the survival in mice beared with S-180.ATF inhibited the pulmonary metastasis in mice beared with of LA-795 lung adenocarcinoma.The biochemical property of ATF and its antitumor mechanism are discussed in this paper.
出处
《实用肿瘤杂志》
CAS
北大核心
1995年第1期39-41,共3页
Journal of Practical Oncology
