摘要
本实验发现家兔急性心肌缺血后血中脂质过氧化物代谢产物丙二醛明显升高，且于２４、４８小时达到峰值，提示氧自由基在急性心肌缺血中起着重要作用。本研究还发现：４８小时血情丙二醛水平与心肌梗塞面积呈正相关，为急性心肌梗塞诊断提供了辅助性指标。
The objective of this study was to obesrve the serial Changes of serum malondialdehyde (MDA) levels after myocardial infarction and assessing the relationships between the peak values of MDA and myocardial infarct size. 16 New Zealand rabbits were divided into an ischemic group (n=10) and a control group (n = 6). Left ventricular branch (LVB) of coronary artery was ligated at its middle third in the ischemic group but shammed ligated in the control group. Serum MDA levels were determined by thiobarbituric acid spectrophotometry before operation and 0. 5. 3, 9. 24 and 48 hours after ligation. Dual staining technique was used 48 hours after ligation to determine infarct size.The results showed that serum MDA levels were increased gradually in control group after operation and in ischemic group after ligation and rosed to the peak value at 24 and 48 hours. Significant correlation was found between 48-hour serum MDA levels and 48-hour infarct size in ischemic group. The linear regression equation was: Y=0. 34 + 2. 46X,r=0. 771. P<0.01. Thus serum MDA levels might be regarded as an unspecific criterion for MI and be used to estimate the infarct size.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
1995年第1期14-16,共3页
Journal of Biomedical Engineering
