摘要
突触素Ⅰ（ｓｙｎａｐｓｉｎⅠ）是神经元特有的一类与小型突触囊泡外侧相连的磷蛋白．该蛋白在进化过程中是比较保守的，其基因位于Ｘ染色体上．通过基因重组产生的小鼠ＳｙｎａｐｓｉｎⅠ基因的零突变及脑片电生理学的观察，发现ｓｙｎａｐｓｉｎⅠ在神经递质释放及突触可塑性等生理活动过程中具有重要作用．
Synapsin Ⅰis a specific phospho- protein of neuron,it is associated with the cy- toplasmic surface of small synapsic vesicles. Itis highly conservative in evolution and its genelocates in X-chromosome. By means of nullmutation of synapsin Ⅰgene in mice and in-vestigation of brain slices electrophy-siologically,the mutation is generated by ho-mologous recombination. And it is found thatsynapsin Ⅰ plays a vital role in physiologicalevents suchas neurotransmitter release andsynaptic plasticity,etc.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
1995年第5期422-426,共5页
Progress In Biochemistry and Biophysics
基金
国家自然科学基金
关键词
突触素Ⅰ
突触囊泡
生物学特性
synapsin ,synapsic vesicles,phosphorylation,neurotransmitter release,synaptic plasticity
